p38 MAPK in complex with inhibitors

Figure 4.a

p38 MAPK14 (blue) bound in a complex with a non-competetive inhibitor BIRB-796 (red) at the binding pocket. The conserved TXY motif has been removed, enabling visualisation of the binding pocket complex. The structure has been visualised with the sticks display model

Figure 4.b

Here the above structure has been visualised using the spacefill display model.

Figure 5.a

Here p38 MAPK14 (blue) is in complex with the competetive inhibitor SB220025 (red) at the kinase binding pocket. Displayed using the sticks display model.

Figure 5.b

Here the above kinase-inhibitor complex has been displayed using the spacefill display model. Binding site colour changed for clarity.

p38 MAPK

p38 Mitogen

Activated Protein Kinase