p38 MAPK
p38 Mitogen
Activated Protein Kinase
 Homo sapiens |  Danio rerio |  Macaca fascicularis |
|---|---|---|
 Mus musculus |  Rattus norvegicus |  Xenopus tropicalis |
Description of sequences producing significant alignments to Homo sapiens.
Description of sequences producing significant alignments to Xenopus tropicalis.
The BLAST results show p38δ in all 6 species are all similar and have a catalytic domain of the Serine & Threonine Kinase (STK). It catalyses the transfer of phosphate from ATP to serine/threonine residues to protein substrates. The results also show the p38δ of human, mouse and rat have several binding sites including ATP, lipid and polypeptide substrate, a KIM docking site and an activation loop. The rest of the p38γ have a ATP binding site only. The position of these binding sites are different to other paralogues.
Detailed BLAST results for MAPK13 orthologues:
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Human (Homo sapiens)
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Crab-eating macaque (Macaca fascicularis)
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Norwegian rat (Rattus norvegicus)
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House mouse (Mus musculus)
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Zebrafish (Danio rario)
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Western clawed frog (Xenopus tropicalis)