p38 MAPK
p38 Mitogen
Activated Protein Kinase
 Homo sapiensSTK domain, start from amino acid 24 to 308. | Danio rerioSTK domain, start from amino acid 25 to 309. |  Macaca fascicularisSTK domain, start from amino acid 24 to 308. |
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 Mus musculusSTK domain, start from amino acid 24 to 308. |  Rattus norvegicusSTK domain, start from amino acid 24 to 308. |  Xenopus tropicalisSTK domain, start from amino acid 25 to 309. |
Description of sequences producing significant alignments to Homo sapiens.
Description of sequences producing significant alignments to Xenopus tropicalis .
The BLAST results show p38⍺ in all 6 species are similar and have a catalytic domain of the Serine & Threonine Kinase (STK). It catalyses the transfer of phosphate from ATP to serine/threonine residues to protein substrates. The results also p38⍺ has several binding sites including ATP, lipid and polypeptide substrate, a KIM docking site and an activation loop. The position of these binding sites are different to other paralogues.
Detailed BLAST results for MAPK14 orthologues:
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Human (Homo sapiens)
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Crab-eating macaque (Macaca fascicularis)
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Norwegian rat (Rattus norvegicus)
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House mouse (Mus musculus)
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Zebrafish (Danio rario)
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Western clawed frog (Xenopus tropicalis)